Smartox Biotechnology是*一家專門生產動物毒液多肽毒素，用于細胞離子通道功能研究的生物醫藥公司。多肽毒素在生物制藥領域具有重要的使用價值。

APETx2    ASIC3 selective inhibitor(酸敏感離子通道3 (ASIC3 )選擇性抑制劑)

 

APETx2 is a toxin that was originally isolated from Anthopleura elegantissima (Sea anemone). selectively blocks the H(+)-gated sodium channel ASIC3 (ACCN3). The blockage is rapid and reversible. This toxin does not block isoform ASIC1a (unlike Psalmotoxin 1) and isoform ASIC1b of ASIC1 (ACCN2), nor ASIC2 (ACCN1). It also inhibits the heteromeric ASIC2b-ASIC3 channel, and has less affinity for ASIC1b-ASIC3, ASIC1a-ASIC3, and no effect on the ASIC2a-ASIC3 channels. IC₅₀ is 63 nM on ASIC3 channel. IC₅₀ is 117 nM on ASIC2b-ASIC3 heteromeric channel. IC₅₀ is 0.9 µM on ASIC1b-ASIC3 heteromeric channel. IC₅₀ is 2 µM on ASIC1a-ASIC3 heteromeric channel. Interestingly, recent studies demonstrated that also inhibits Na_v1.8 currents with an IC₅₀ of around 2 µM.

 

技術資料

氨基酸序列：

 H-Gly-Thr-Ala-Cys⁴-Ser-Cys⁶-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys²⁰-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys³⁰-Arg-Tyr-Phe-Leu-Gly-Thr-Cys³⁷-Cys³⁸-Thr-Pro-Ala-Asp-OH

二硫鍵： Disulfide bonds between Cys⁴-Cys³⁷, Cys⁶-Cys³⁰ and Cys²⁰-Cys³⁸

長度 (aa)：42

分子式： C₁₉₆H₂₈₀N₅₄O₆₁S₆ 

分子量：  4561.13 Da

外觀：White lyophilized solid 

可溶性： water and saline buffer

CAS 號： not available 

來源： Synthetic 

純度： > 98%

 

產品信息

07APE002-00100		0.1mg
07APE002-00500		0.5mg
07APE002-01000		1mg