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The solid phases in CHIROBIOTIC™* columns are based on covalently bonding macrocyclic glycopeptides to a high purity 15 micron silica in such a way as to establish its stability while retaining essential components for chiral recognition.

The new Astec CHIROBIOTIC columns for SMBC feature 5 cm x 10 mm I.D column dimensions for lower back pressure and higher flow rate, making them ideal for use on the new bench-scale Semba Octave™ SMB Chromatography System. Use the corresponding 25 cm x 4.6 mm I.D. column for method development.

* Manufactured by and trademark of Supelco/Sigma-Aldrich

• Rugged and reproducible for long term, reliable operation
• Enantioselective for a wide range of chiral compounds
• Flexible phases for optimum sample solubility and operation without memory effects

CHIROBIOTIC V2 is based on bonding Vancomycin, which contains 18 chiral centers surrounding three pockets or cavities. Five aromatic ring structures bridge these strategic cavities. Hydrogen donor acceptor sites are readily available close to the ring structures.

CHIROBIOTIC T is based on bonding the amphoteric glycopeptide, Teicoplanin, which contains 23 chiral centers surrounding four pockets or cavities.

These CSPs offer phase flexibility and are stable from 0-* organic modifier.