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【產品簡介】
【詳細說明】
Tamapin
Selective blocker of SK2 (KCa2.2) channels
SK2 (KCa2.2)通道選擇性阻斷劑
Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. Tamapin is amidated at its C-terminal tyrosine residue. Tamapin binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to Apamin or Leiurotoxin-1 (Scyllatoxin), Tamapinis an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM).
Tamapin技術資料
氨基酸序列：
Ala-Phe-Cys3-Asn-Leu-Arg-Arg-Cys8-Glu-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21 -Ile-Gly-Glu-Glu-Cys26-Lys -Cys28-Val-Pro-Tyr-NH2
二硫鍵： Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
長度（aa）： 31
分子式：C146H237N44O41S6
分子量： 3459.00 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS號： not available
來源：Synthetic
純度：> 97 %
產品信息
10TAM001-00100 | Tamapin | 0.1mg |
10TAM001-00500 | Tamapin | 0.5mg |
10TAM001-01000 | Tamapin | 1mg |