僅用于工業應用或科學研究，不可用于人類或動物的臨床診斷或治療，非藥用. Spesolimab （BI 655130） is an anti-IL-36R antibody. IL-36 involves in immune system, as Spesolimab can be used for palmoplantar pustulosis （PPP） research. Spesolimab is associated with the reduction of biomarkers linked to innate, Th1/Th17, and neutrophilic pathways