詳細介紹
GATA3 心肌轉錄因子3(鼠單克隆抗體)
廣州健侖生物科技有限公司
GATA3是一種鋅指轉錄因子,在許多組織中參與激發、引導細胞增殖、成長、分化。但在腫瘤組織中,GATA3排它性地主要在乳腺癌和泌尿道上皮癌表達。有報道GATA3在乳腺癌的表達與ER,PR和Her2有相關性;在泌尿道上皮癌的表達與腫瘤的侵潤性和級別呈正相關。
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GATA3 心肌轉錄因子3(鼠單克隆抗體)
【產品介紹】
細胞定位:細胞核
克隆號:L50-823
同型:IgG1/K
適用組織:石蠟/冰凍
陽性對照:乳腺癌/尿路上皮癌
抗原修復:熱修復
抗體孵育時間:30-60min
產品編號 | 抗體名稱 | 克隆型別 |
OB108 | ERCC1(人切除修復交叉互補基因1) | SP68 |
OB109 | ERG | EP111 |
OB110 | Factor Ⅷ(第八因子相關抗原) | polyclonal |
OB111 | Factor ⅩⅢa(第十三因子a) | EP3372 |
OB112 | FSH(卵泡刺激素) | polyclonal |
OB113 | Galectin-3(半乳糖凝集素-3) | 9C4 |
OB114 | GATA3(心肌轉錄因子3) | L50-823 |
OB115 | GCDFP-15(巨囊性病液體蛋白15) | EP1582Y |
OB116 | GFAP(膠質纖維酸性蛋白) | EP672Y |
OB117 | GH(生長激素) | polyclonal |
OB118 | Glucagon(胰高血糖素) | polyclonal |
OB119 | GLUT1(葡萄糖轉化酶) | polyclonal |
OB120 | Glycophorin A(血型糖蛋白A)或CD235a | GA-R2&HIR2 |
OB121 | Glypican-3(磷脂酰肌醇蛋白聚糖3) | 1G12 |
OB122 | Granzyme B(粒酶B) | polyclonal |
OB123 | GS(谷氨酰胺合成酶) | GS-6 |
GATA3 心肌轉錄因子3(鼠單克隆抗體)
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【公司名稱】 廣州健侖生物科技有限公司
【市場部】 歐
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【騰訊 】
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室
這項研究意味著人們可以開發出精確的基因療法來預防和治療疾病,是高度個性化醫療的曙光。個性化醫療是非常重要的,因為人的個體差異對疾病發展影響很大。
CRISPR/Cas9是時下zui熱門的基因編輯系統,Cas9蛋白可以說是基因工程的瑞士抗原抗體,可以結合并切割任意DNA。Church等人以一種新方式使用Cas9,讓它激活特定基因的轉錄,從而表達或抑制特定的遺傳學性狀。他們把Cas9與延長了三倍的轉錄因子融合起來,使其能夠強力控制單個或多個基因的表達。
“在基因工程領域,能控制遺傳學性狀的旋鈕越多越好,”Church說。“我們展示了一類全新的旋鈕,它們可以控制多個基因,決定特定遺傳學性狀的表達或表達程度。現在我們可以極為精確的上調或下調基因表達。”研究人員在體外培養的酵母、果蠅、小鼠和人類細胞中證實了這一技術操縱基因表達的能力。
人類基因組90%的區域并不翻譯成蛋白質,曾經被認為是無用的垃圾。后來人們發現,這一區域的基因以一種神秘的方式起作用,而且這些基因往往串聯起來發揮作用。Church等人開發的新方法,可以靶標和激活這些人們知之甚少的DNA暗物質。
This research means that people can develop precise gene therapy to prevent and cure diseases, which is the dawn of highly personalized medicine. Personalized medical care is very important, because individual differences in human beings have a great impact on disease development.
CRISPR / Cas9 is the hottest gene editing system of the moment. Cas9 protein is a genetically engineered Swiss antigen antibody that binds and cleaves any DNA. Church et al. Use Cas9 in a new way to activate the transcription of specific genes to express or suppress specific genetic traits. They fused Cas9 with a threefold-longer transcription factor, enabling them to aggressively control the expression of single or multiple genes.
"In genetic engineering, the more knobs that control genetic traits, the better," Church said. "We showed a new class of knobs that control multiple genes and determine the level of expression or expression of specific genetic traits, and we can now very accuray up-regulate or down-regulate them." The researchers studied in vitro yeast The ability of the technique to manipulate gene expression is confirmed in flies, mice and human cells.
Ninety percent of the human genome is not translated into protein and was once considered useless rubbish. It was later discovered that the genes in this area functioned in a mystical way, and these genes tended to work in tandem. The new method developed by Church et al. Targets and activates these poorly understood DNA dark substances.