CRANAD 2 （1193447-34-5）is a near-infrared probe that binds to Aβ40 aggregates and elicits an emission blue shift. It was shown to bind to plaques in APP-PS1 transgenic mice, in vitro.

Biochem/physiol Actions

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

CAS:1193447-34-5

 

• 中文名稱：CRANAD-2

 

• 英文名稱：CRANAD-2

 

• 英文別名：(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron

 

• CAS號：1193447-34-5

 

• 分子式：C23H25BF2N2O2

 

• 分子量：410.26500

 

• 精確質量：410.19800

 

• PSA：32.78000

 

• LogP：4.93870

• 外觀與性狀：深藍色或黑色粉末

 

• 可溶性：DMSO: soluble 0.2 mg/mL, clear (warmed)