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抑制劑ARN 272，CAS:488793-85-7
FAAH樣anandamide轉(zhuǎn)運(yùn)蛋白（FLAT）抑制劑（IC50 = 1.8μM）; 結(jié)合anandamide的FAAH-1的胞質(zhì)變體。 分別在體外和體內(nèi)減輕anandamide內(nèi)化和失活。 在CB1介導(dǎo)的傷害性和炎性疼痛的嚙齒動(dòng)物模型中展現(xiàn)止痛作用。
| M. Wt | 432.47 |
| Formula | C27H20N4O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 488793-85-7 |
| PubChem ID | 24802717 |
| InChI Key | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| Smiles | OC(C=C4)=CC=C4C2=NN=C(NC3=CC=C(C(NC5=CC=CC=C5)=O)C=C3)C1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 | |
| ethanol | 8.65 | 20 |
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