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BRCA1 rabbit pAb3
  • BRCA1 rabbit pAb3
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更新時間:2025-06-28 12:16:17

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SourceRabbitApplicationsWB,IHC,IF,ELISAReactivityHuman,RatDilutionWB:1:500-1:2000
  • Source

    Rabbit

  • Applications

    WB,IHC,IF,ELISA

  • Reactivity

    Human,Rat

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    BRCA1 Polyclonal Antibody detects endogenous levels of BRCA1 protein.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human BRCA1. AA range:1391-1440

  • Uniprot No

    P38398

  • Alternative names

    BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    BRCA1, DNA repair associated(BRCA1) Homo sapiens This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian

  • Other

    BRCA1, Breast cancer type 1 susceptibility protein

  • Mol.Wt (Da)

    207721

  • Concentration

    1 mg/ml

Product Reactivity Applications Conjugation Catalog Images

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