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產品英文名稱 | Human IL-17A Protein |
產品中文名稱 | 17A(IL-17A) |
別名 | interleukin 17A, CTLA-8, IL17, IL17A |
表達宿主 | 大腸桿菌 |
種屬 | 人 |
序列 | 氨基酸序列來源于:人IL-17A (Ile20-Ala155) (Q16552) 表達的蛋白片段。 |
活性 | Testing in progress. |
蛋白長度 | 重組人IL-17A由136個氨基酸組成,預測分子量為15.7 KD。 |
純度 | > 98% ,使用SDS-PAGE檢測 |
特點&優勢 | 通過LAL法測定,每微克蛋白里內毒素含量<0.1>0.1> |
產品形式 | 凍干粉,凍干緩沖液為無菌的20 mM Tris,50 mM NaCl,pH 8.0。 |
基因ID | 3605 |
蛋白序列鏈接 | /uniprotkb/Q16552/entry#sequences |
使用中注意事項 | 開蓋使用前,請先離心。本產品為凍干粉,推薦用該產品配套的Reconstitution Buffer進行復溶,且濃度不低于100 µg/mL。客戶可根據后續的實驗需求,進行進一步的稀釋。 |
保存建議 | 本產品為凍干粉形式,建議:將凍干粉產品保存于-20℃以下的干燥環境中。本產品溶解之后,可在4℃保存2-7天,長期使用請置于-20℃以下。為長期保存,推薦添加載體蛋白(0.1% HSA或者BSA),并酌情分裝保存,避免反復凍融。 |
運輸條件 | 冰袋運輸(藍冰) |
警告 | 本文列出的產品僅供研究使用,不適用于人類或臨床診斷。我們產品所推薦應用,不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發生的侵權或其他違規行為,我們不承擔任何責任。 |
背景 | Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+T cells. In addition to Th17 cells, IL-17A can also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6. |
Fig.Human IL-17A Protein