久久国产精品午夜一区_91精品國產高清久久久久久91_?级毛片免费全部播放_欧美色图在线视频一区二区三区_国产综合亚洲一区二区三区_中文字幕熟女网_国产精品男人爽免费视频_九九无码网战_亚洲日本三级电影在线观看_欧美日韩DVD手机在线不卡

CD36, also known as cluster of differentiation 36, is an 88-kDa integral membrane glycoprotein expressed on various cell types, including platelets, monocytes, adipocytes, hepatocytes, myocytes, and microvascular endothelial cells. It functions as a class B scavenger receptor that binds multiple ligands such as long-chain fatty acids, oxidized low-density lipoprotein （oxLDL）, collagen, thrombospondin, and anionic phospholipids. CD36 plays a crucial role in lipid metabolism, facilitating the uptake of fatty acids and contributing to lipid accumulation under excessive fat supply. In the context of cancer, CD36 is overexpressed in several types of tumors, including breast, brain, and ovarian cancers, where it promotes tumor growth, migration, and metastasis by supporting lipid metabolism and metabolic reprogramming. Additionally, CD36 is involved in immune responses and drug resistance in cancer cells. Its dysregulated expression is associated with poor prognosis in various cancers. Recent research has focused on developing CD36-targeted therapies, such as small-molecule inhibitors and antibodies, to address its role in cancer progression.