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Insulin-like growth factor-II （IGF-II） is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase （IGF-1R） mediates IGF-II actions, and a family of six high affinity IGF binding proteins （IGFBPs） regulates IGF-II circulating half-life and its availability to bind IGF-1R.