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文獻名：Autodegradable clusters made from superparamagnetic nanoparticles with drug release properties 

 

作者：Xiaonan Liu, Minhao Yan, Congfen Zhang& Jinshan Li

State Key Laboratory for Environment-friendly Energy Materials, Southwest University of Science & Technology, Mianyang, 621010, PR China

Institute of Chemical Materials China Academy of Engineering Physics (CAEP), Mianyang, 621900, PR China

 

摘要：Aim: The agglomeration of nanoparticles plays an important role in the preparation of nanostructured materials, which have implication in the practical applications such as plasma nanosensor and drug release. Materials & methods: Highly stable individual superparamagnetic γ-Fe2O3 nanoparticles with diameter of 5 nm were first synthesized in water. These particles were then assembled into spherical clusters with diameters of approximately 200 nm by using a simple and versatile method. Results: The prepared γ-Fe2O3 nanoparticle-based clusters were then used for aminophylline drug loading and release properties investigation. The results show the high drug load rate, release speed and release rate. Conclusion: The present materials and method present great potential in drug release application.