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文獻名： Bi₁₉S₂₇I₃ nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

 

 

作者： Jinsong Xiong, ^a   Qinghuan Bian, ^a   Shuijin Lei,  ^a   Yatian Deng,^a   Kehan Zhao,^a   Shunqiang Sun,^a   Qi Fu,^a   Yanhe Xiao^a  and  Baochang Cheng ^a  

^a School of Materials Science and Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China

 

摘要：Near-infrared (NIR) light-induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in photothermal therapy systems, a variety of photothermal agents have been developed. However, the exploration of novel photothermal therapy nanoplatforms with high NIR absorption remains a significant challenge, especially those working in both NIR-I and NIR-II windows. In this work, Bi₁₉S₂₇I₃ nanorods with remarkably high absorption covering the whole visible light to the entire NIR-I and NIR-II regions have been successfully prepared through a facile solvothermal approach. The as-synthesized Bi₁₉S₂₇I₃ nanorods have a high photothermal conversion efficiency of 42.7% at 808 nm (NIR-I) and 41.5% at 1064 nm (NIR-II), making them a promising candidate for photothermal therapy. In vitro cell viability assay reveals that the Bi₁₉S₂₇I₃ sample has good biocompatibility and exhibits significant cell-killing effect under NIR irradiation. In vivo anti-tumor experiments demonstrate that the tumor growth can be effectively inhibited by fatal hyperthermia ablation mediated by Bi₁₉S₂₇I₃ nanorods under the irradiation of an 808 nm or 1064 nm laser. Therefore, this study should be primarily beneficial for the development of new materials for NIR photothermal therapy applications.

 

 

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